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Increased FOXO4 expression correlates with enhanced proteasomal activity, leading to a reduction in the accumulation of damaged proteins, particularly in cardiovascular tissue

on the other hand, GSH depletion could improve the susceptibility of cancer cells to various forms of programmed cell death and improve sensitivity to chemotherapy

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Plant Cell Physiol 46:15151524 Nelson DE, Rammesmayer G, Bohnert HJ (1998) Regulation of cell-specific inositol metabolism and transport in plant salinity tolerance