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Diabetes 48:754757 Fonseca SG, Urano F, Weir GC, Gromada J, Burcin M (2012) Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

Auto-Abs in TED are commonly of the IgG1 subclass [158, 159], and more recently, studies have established that elevated IgG4 levels may also drive the disease in a portion of diagnosed patients [160]

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BP drops faster than weight loss alone would predict, sometimes to 100/60 or lower, with orthostatic symptoms

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