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Nutrients 11, 1991
In addition, in vitro interventions with chloroquine and quinacrine in HEK293 cells transfected with TLR3, TLR8, and TLR9 demonstrated a dose-dependent decrease in IL-6 in the culture supernatant and the expression levels of the three proteins, indicating that artemisinin analogs such as chloroquine and quinacrine can alleviate SLE symptoms by inhibiting TLR signaling pathways (139)
doi: Spiering, B.A., Kraemer, W.J., Hatfield, D.L., Vingren, J.L., Fragala, M.S., Ho, J.-Y., Thomas, G.A., Hkkinen, K
Zeisel, S
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