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When it enters the cell, it chemically modifies specific cysteine residues on the Keap1 protein (most notably Cys151)
All other OMMs, but not liraglutide and semaglutide, exerted significant favorable effects on systolic blood pressure and some (phentermine plus topiramate, tirzepatide and orlistat) on diastolic blood pressure (Table 1)
The only treatments associated with a lower risk of cardiovascular mortality, on the other hand, were semaglutide and naltrexone/bupropion
Last reviewed: May 22, 2026 Last updated: May 22, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
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