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Acral lentiginous melanoma (ALM) can be difficult to diagnosis and has a lower response rate to available therapies for cutaneous melanoma, such as immune checkpoint inhibitors, but survival in the metastatic setting is second only to pure cutaneous melanoma
[11:52] Dr
Retrieved 6 January 2024
Both influence the PPAR-gamma transcription factor, which regulates lipid metabolism
This is why light exclusion matters: UV photons generate ROS in aqueous solution, oxidizing the aromatic residues and reducing receptor binding affinity
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