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Mental stress Mental stress has emerged as an important risk factor for the development of CVD [122,123] as it promotes early vascular aging phenotypes [124] , as reviewed in detail elsewhere [122,123,125]

Further OS-mediated tissue damage causes inflammation that activates nuclear transcription factor-kappa B (NF-B) signaling pathway in brain and further exaggerates neurological disorders[44]

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S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-B signaling pathway in mice

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In summary, we show for the first time that peripheral markers of oxidative stress and damage previously observed in plasma and immune cells are similarly elevated in two affected brain regions in autism, cerebellum and BA22