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Quanjer, P
Janus kinase inhibitors in the treatment of vitiligo: A review
JAM-C can maintain the EC in a polarized manner, creating a unidirectional gate for neutrophil movement from the vascular lumen to the proximal tissue compartment, whereas the effects of NE and certain acute inflammatory conditions, such as ischemia-reperfusion injury, may impair this gate by downregulating the expression of JAM-C
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Schdel J, Ratcliffe PJ
Increased biopterin levels boost the formation of H2O2 and inhibit the function of phenylalanine and tyrosine hydroxylases, thus impairing melanin production in melanocytes and inducing norepinephrine accumulation in keratinocytes [6].Biopterins act as inhibitors of the enzymes involved in melanogenesis (namely, phenylalanine hydroxylase and tyrosinase) and stimulate the formation of H2O2
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