In HG-treated HK-2 and HFD/STZ-induced C57BL/6J mouse models, Finerenone (FIN) was found to restore mitophagy, reduce oxidative stress and apoptosis, and alleviate renal tubular injury through the PI3K/Akt/eNOS signaling pathway, thus exerting a certain therapeutic effect on DKD [139]
Nature Reviews Drug Discovery, 21(3), 201223
Caffeine (but judiciously): if you feel like you need a pick me up, caffeine can help
This translates into clinically proven, natural-feeling benefits through: Optimized Appetite Control: Clinical studies demonstrate that Tirzepatide acts on GIP and GLP-1 receptors in the brain, sending powerful signals of fullness and satisfaction
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