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doi: 10.3109/21678421.2014.906618 346 KwanJYJeongSYVan GelderenPDengHXQuezadoMMDanielianLEet al

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Systematic Review Registration: identifier 10.17605/OSF.IO/ZYHWS Highlights GLP-1 receptor agonists combined with metformin produced the greatest reductions in body weight and BMI among women with PCOS GLP-1 monotherapy significantly reduced waist circumference, whereas no treatment demonstrated a statistically significant effect on HOMA-IR These findings support GLP-1based therapies as the most effective pharmacologic strategy for anthropometric improvement in women with metabolically active PCOS

IU, international units