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Interestingly, this effect was mediated by the release of CCK and GLP-1 and subsequent activation of their receptors, possibly on VANs (see Hormonal gut-brain signaling section)
The information provided here is based on animal research extrapolation and anecdotal reports from researchers and enthusiasts in the community
More serious considerations the evaluating clinician will screen for include a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (GLP-1 medications carry a boxed warning for thyroid C-cell tumors based on animal studies), a history of pancreatitis, gallbladder disease, and severe gastrointestinal conditions
This gut-first approach makes it appealing to those who want a sustainable, non-invasive alternative to prescription medications
Treat yourself as a new drinker discovering your limits for the first time
Even if you have been on GLP-1 medications for months, your provider may still suggest a brief titration period for the new medication
