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Beneficial effects of IGF-I treatment in ALS have been demonstrated both in vivo and in vitro , from which IGF-I has been postulated as an important factor for the maintenance and survival of motor neurons in the spinal cord by activating clue pathways as PI3K/Akt and p44/42 MAPK[333] and ameliorating the superoxide effect[334]

Together, they support growth hormone release, recovery, and muscle repair, making them one of the most frequently chosen stacks for lean mass development

Jul 22 2020;21(15)doi:10.3390/ijms21155175