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Liraglutide and exendin-4 are initially antidiabetic drugs but can affect tumorigenesis, suggesting GLP-1R agonists as a potential treatment for different cancers as found in vivo (Table 2)

MAPK participates in the intracellular signaling to: (1) induce the gene expression of redox sensitive transcription factors, such as activator protein-1 (AP-1) and nuclear factor B (NF-B) (Pinkus et al., 1996), (2) stimulate apoptosis (Clement and Pervaiz, 1999), and (3) modulate cell proliferation (Lundberg et al., 2000)

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[33] They may also be selected to address any possible psychiatric comorbidities