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Practical Diabetes 37(5):194195

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Clinical evidence demonstrates that semaglutide typically improves liver enzyme profiles, particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

Combined, these changes can make you feel colder than before

However, no known interaction does not always mean no effect. Because both substances influence how your body handles sugar and insulin, they may have an additive effect

Further research is needed to elucidate the exact pathophysiological mechanisms involved and to understand the trade-offs between the benefits and risks of GLP-1 RAs, the study authors concluded