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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Such instabilities may compromise the integrity of the vesicular structure, resulting in premature drug leakage and uncontrolled release kinetics

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Originally developed for T2D, these agents enhance insulin sensitivity by reducing insulin resistance, as demonstrated by significant declines in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) scores

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