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qRT-PCR analysis revealed the marked upregulation of CDKN2A (encoding p16) , CDKN1A (encoding p21) , interleukin-8 ( IL-8) , and matrix metalloproteinase ( MMP)-12 expression (Figure 1D)
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Notably, the G/D-CuP group showed the lowest ratio of CD86-positive macrophages/CD206-positive macrophages, indicating an enhanced M1-to-M2 transition (Supplementary Fig
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10.1021/acschemneuro.1c00083 Summary Keywords melatonin, dexmedetomidine, electroencephalography, EEG, sleep, sleep induction Citation Peganc Nuni K, Neubauer D, Oraem Mrak J, Perkovi Benedik M, Mahne U, Bizjak N, Rener Primec Z, utar N, Butenko T, Vraj E and Osredkar D (2024) Melatonin vs