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Preclinical and clinical data suggest that FXR and PPAR dual modulators can improve insulin sensitivity, reduce hepatic steatosis, and attenuate fibrosis, which may complement the actions of GLP-1/GIP/GCG receptors agonists
doi 10.1111/imm.13784 87 SkarbalieneJMathiesenJMLarsenBDThorkildsenCPetersenYM
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Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos
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others are promising but less studied
