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Funding This work was supported by the National Major Scientific and Technological Special Project for Significant New Drugs Development during the Thirteenth Five-year Plan Period (Grant number: 2020ZX09201-003), National Natural Science Foundation of China (Grant number: 32000985), Key Disciplines Construction Program of Traditional Chinese Medicine (Integrated Traditional Chinese and Western Medicine) during the Thirteenth Five-year Plan Period of Zhejiang province (Grant number: 2017-XK-A35), Zhejiang Provincial Natural Science Foundation (Grant number: LQ21H300003), Zhejiang Province Medical and Health Science Research Project (Grant number: 2021KY666), and Zhejiang Pharmaceutical Association (Grant number: 2019ZYY12)

Furthermore, available data suggest a key role for IGFs both as a link between insulin resistance syndrome and cancer, and as a driver of cancer drug resistance associated with metabolic syndrome

10.1021/bi011459o Biochemistry 104 PompellaA.CortiA.PaolicchiA.GiommarelliC.ZuninoF

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We can expect to see a dynamic and fast-moving field with research and regulatory activity shaping the future of diabetes and weight loss treatments in 2025

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