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In a rat model of diabetes-induced testicular dysfunction, liraglutide reduced testicular TGF- and Smad2 mRNA expression levels [26], whilst in HUVECs, liraglutide attenuated high glucose and IL-1-induced TGF- signalling (via inhibition of Smad2 phosphorylation), leading to reduced endothelial-to-mesenchymal transition (EndMT) marker expression [27]
Yan Etkiler Var m
Lifestyle factors that support metabolic health and may influence GLP-1 function: Regular physical activity : Exercise improves insulin sensitivity and may enhance incretin response, with both aerobic and resistance training showing benefits
The authors recommend providing in-depth counselling and possibly slower titration of GLP-1 RAs during initiation in these groups, particularly those who are known to have discontinued metformin previously, in order to decrease discontinuation rates
