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2009 Sep;139(9):1744-50

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as levels normalise, improved daytime energy may temporarily affect sleep-wake cycles Individual sensitivity : A small subset of people may be more sensitive to changes in B vitamin levels Formulation factors : Some B12 supplements contain additional ingredients that could affect sleepalways check product labels for stimulants like caffeine For the vast majority of people, vitamin B12 supplementation does not cause sleep disturbances when taken as directed