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Semaglutide and tirzepatide are not metabolized through cytochrome P450 enzymes, so they dont affect SSRI metabolism

Variants in the GIPR gene have been independently associated with BMI, fat distribution, and response to dual incretin agonism

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That gap, between almost everyone feels something and almost nobody quits over it, is where the useful information lives

When meals are high in fat, the lower oesophageal sphincter relaxes more easily and the stomach clears more slowly, so pressure builds and acid has more opportunity to move upward

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