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One study that is needed is a prospective randomized trial comparing the GLP-1/GIP agonists to placebo that has sound methodology and primary ocular outcomes

The primary outcomes were the percentage weight change and the proportion of participants losing at least 5% of their baseline weight, using treatment-policy estimand analysis (intention-to-treat principle)

Clinical trials would need to assess both hemodynamic parameters and clinical outcomes including walking distance, pain scores, and amputation rates to establish therapeutic benefit

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