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Quality sleep (7-9 hours) is key during the first few weeks of treatment
The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses
Take 2 capsules of each daily
Teraoka et al
This effect is achieved through the activation of signaling pathways such as the ERK1/2, PI3K/AKT, and cAMP/PKA/-cat-Ser675 pathways, which are mediated by GLP-1RAs
Supplementation has also be thought to reduce inflammation and improve nutritional status in these patients, although a recent study found no significant difference in participants that supplemented orally with glutathione
