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A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

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Signs of degradation are usually visible

But the peptide bonds are slowly breaking down, reducing potency with each passing day above optimal temperature

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In the tirzepatide trials, nearly 9 out of 10 participants on the higher doses achieved clinically meaningful weight loss