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Many people prefer a natural approach, and many do best with a combined strategy

Evidencing changes indicate the possibility of prebiotics having neuroprotective, stress-buffering effects through the modulation of the MGBA by restoring microbial homeostasis, changing neuroendocrine responses, or affecting gene expression in stress-related brain regions (Burokas et al., 2017)

A 2024 pilot study tracking 48 research subjects using tesofensine 0.5mg daily plus tirzepatide 5mg weekly found additive fat loss (tesofensine contributed central appetite suppression

Fat MN, et al

It is important to note that insulin does not increase glucose uptake into neurons via the insulin-sensitive glucose uptake transporter 4 (GLUT4)

Volume replacement and stimulation of collagen production using biostimulating fillers such as Radiesse (CaHA) or Sculptra (PLLA)