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Other antioxidants, including salidroside which protects erythrocytes against H 2 O 2 -induced eryptosis by enhancing antioxidant enzyme activity (Qian et al., 2012), Trolox (a water-soluble vitamin E analog that inhibits ROS-driven Ca 2+ entry and eryptosis (Celik et al., 2024), and GSH itself which directly neutralizes ROS and maintains redox homeostasis in erythrocytes (Georgiou-Siafis and Tsiftsoglou, 2023), further support the role of antioxidant-based strategies in suppressing eryptosis

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however, the long-term impact on CV outcomes was inconclusive [7]

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FDA could also be requesting COAs from manufacturers, along with samples of product, and then testing them for potential impurities, informed by engagement on CMC sections for already submitted ANDAs