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16 Substituting GLP-1 (737) Tyr 19 with Ala notably decreased both the affinity and activity (IC 50 : 0.27 nM3.5 nM;EC 50 : 2.6 nM55 nM)
A general linear model (GLM) was evaluated to determine if dependent variables (nAR and nAR) were significantly related to the independent parameters: equilibrium stress (s eq ), the change in s eq from 110% strain, |E*|, tan, collagen disorganization (CSD), the change CSD from 110% strain (CSD), cell number, F-actin, fiber mean slack length (SL_mn), nuclear disorganization (nCSD), and the change in nCSD from 110% strain (nCSD)
Additionally, one of the study authors reports receiving an investigator-initiated grant, on behalf of the University of Pennsylvania, from Novo Nordisk and receiving consulting fees from Currax Pharmaceuticals, LLC
MitoTracker Red CMXRos fluorescence was detected with an Ex filter of 560/20 nm, a DM filter of 585 nm, and an Em filter of 630/40 nm
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