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Owing to the rapid degradation of GLP-1 by dipeptidyl peptidase type 4 (DPP-4), it is structurally modified into more stable GLP-1R agonists, such as liraglutide, exenatide, and dulaglutide, which share 97%, 53%, and 90% sequence homology, respectively 12

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This is significantly higher than standard recommendations and often requires protein supplementation to achieve

More clinical trials of other peptides are likely, potentially bringing FDA approval and mainstream acceptance to compounds currently limited to research use