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NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure

In clinical trial, it produced roughly a 6% reduction in body weight over 68 weeks

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There are many ways these compounds can be used to study metabolic regulation, so researchers can explore multiple aspects of cellular metabolism

Methionine (an essential amino acid), inositol (a B-complex-associated compound), and choline (an essential nutrient), typically in a preserved sterile solution

Animal studies show that mice prone to obesity have high NNMT levels in their white fat tissue