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Strict Administration Requirements: Rybelsus has very specific instructions that must be followed exactly: Take on empty stomach (first thing in morning before eating or drinking) With no more than 4 ounces of plain water Wait 30 minutes before eating, drinking, or taking other medications Swallow whole (dont crush, chew, or split) Breaking these rules dramatically reduces absorption and effectiveness

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Although both are analogs of human GLP-1, there are a few molecular differences between these two agents that may be the reason that a hypersensitivity reaction occurred with liraglutide and not semaglutide

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