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Folate antagonism is known to contribute to the antiproliferative effects that are important in the action of methotrexate against malignant diseases, but concomitant administration of folic or folinic acid does not diminish the anti-inflammatory potential of this agent, which suggests that other mechanisms of action might be operative

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Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation

This molecular similarity allows PDRN to "communicate" with our skin cells

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Chabner 2013b)