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The Connectivity Map (CMap) analysis by Iorio et al

Quality control, OTU table generation and bioinformatics analysis was done using the Usearch10 (Edgar RC Flyvbjerg H, 2015) and the Microbiomeanalyst package 52

Off-label use may lead to unintended side effects or ineffective treatment, as the medication may not be suitable for the intended condition

3 Results 3.1 Participant demographics Table 1 summarizes the participant demographics at baseline prior to the start of MAD

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A Phase 2 trial of liraglutide told a related story, with no clear motor benefit but possible gains in non-motor symptoms and quality of life