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Tirzepatide's dual-action approach Tirzepatide (found in Mounjaro and Zepbound) works differently by activating not one, but two hormone receptors: GLP-1 receptors (the same ones that semaglutide targets) GIP (glucose-dependent insulinotropic polypeptide) receptors This dual-action approach creates complementary effects on hunger, metabolism, and blood sugar regulation and yielding more impactful results than GLP-1 alone

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