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& Fouque, D
ROS-activation of Apoptosis Signal-regulating Kinase/c-Jun N-terminal kinase/p38 (ASK1-JNK/p38) and Mitogen-Activated Protein Kinase (MAPK), results in cell death
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Among the compounds that the enzyme reduces there are phospholipids, fatty acids and DNA hydroperoxides produced by lipid peroxidation and oxidative damage to DNA 1
Kaufmann, M., Lee, S
217,218,219 Intriguingly, accumulating studies have revealed the key role of lactylation in cancer epigenetic rewiring (Fig
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