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Physicians are increasingly recognizing semaglutide as an effective pharmacological option for chronic weight management because clinical studies are consistently demonstrating meaningful and sustained weight reduction outcomes

30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself

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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

That has made the drugs blockbuster treatments for type 2 diabetes and obesity