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2 The process of oral and maxillofacial wound healing 2.1 Epithelium of skin and oral mucosa The skin and mucosa of the oral and maxillofacial region, as barriers and protective organs of the body, are important for the maintenance of waterelectrolyte balance and protection of internal tissues and organs from microbial infection and external friction, which would affect their function and esthetics (Wang et al., 2017