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These resistance mechanisms contribute to diminished treatment responsiveness, necessitating the development of precision-based therapies to overcome such barriers (Krishnan et al., 2025b)
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The gentle ramp from 0.25 mg up to 2.4 mg mirrors the phase 2 dose-finding schedule that achieved meaningful weight loss while keeping nausea and other gastrointestinal effects manageable [1] [4]
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Vitamin B12 (as methylcobalamin)
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