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The potential relationship between anti-inflammatory effects of GLP-1 and CAD is shown in Figure 1

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doi: 10.3389/fpsyt.2025.1626103 Received 13 May 2025 Accepted 27 October 2025 Published 17 November 2025 Volume 16 - 2025 Edited by Luciane Cruz Lopes, University of Sorocaba, Brazil Reviewed by Raffaele Carraro, La Princesa University Hospital, Spain Kyle Valentino, University of Toronto, Canada Updates Copyright 2025 Yu, Huang, Lo, Huang, Yang and Kornelius

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in patients with type 2 diabetes mellitus, the incretin effect is responsible for less than 20% of the insulin response to an oral glucose load, whereas it accounts for roughly two-thirds of the response