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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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doi: 10.1093/ndt/gfx377 200 ChertowGMPergolaPEChenFKirbyBJSundyJSPatelUDet al

10.1038/s41563-024-01933-w Nat Mater

Higher dose glutathione IV therapy often costs more due to increased ingredient expense, longer infusion times and additional clinical monitoring