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As highlighted in a recent review, while GLP-1RAs show potential in treating SLE, further prospective investigations are needed to determine if they pose a risk of triggering autoimmune activity and whether their advantages in SLE outweigh such risks [292]

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(PubMed) Cheung MC, Zhao XQ, Chait A, Albers JJ, Brown BG

Upon reaching the distal ileum and colon, these conjugated BAs encounter a dense consortium of anaerobic bacteria, primarily from the phyla Firmicutes and Bacteroidetes , which express specialized enzymes capable of deconjugation, dehydroxylation, epimerization, and oxidation (50)

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Beyond diabetes and weight management, GLP-1 agonists have shown potential benefits in improving heart health and reducing the risk of certain cancers, although more research is needed in these areas