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The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects

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Reduces Lactic Acid Accumulation: It reduces the accumulation of lactic acid in the muscles, decreasing muscle pain and aiding in faster recovery

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