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GSH is synthesized downstream of the conversion of glutamine to glutamate by GLS, which is elevated in a MYCdependent manner 27 (Fig 2B)
Background The relative effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for kidney protection, both individually and in combination, is incompletely understood
Exenatide, an exogenous GLP-1RA, has been shown to enhance hypothalamic connectivity in obese individuals who respond to its anorexigenic effects, while also decreasing food reward-related brain activation
PMID 22575611
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