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They work by slowing digestion, reducing appetite, and improving blood sugar regulation
This effect is likely driven by the prolonged circulating half-lives of long-acting and ultra-long-acting GLP-1RAs, such as semaglutide (via fatty acid acylation) and dulaglutide (via Fc fragment fusion), which maintain sustained GLP-1 receptor stimulation and enhance intestinal motility, thereby increasing diarrhea risk
Mitochondrial autophagy-related proteins (Bnip3 and Optn) were significantly elevated in the HFD group, while lysosome-related protein Atp6v0d1 was significantly downregulated
FDA's Prescription Drug User Fee Act V (PDUFA V) regulation
President of the Obesity Medicine Association
J Manag Care Spec Pharm 30(8):860867
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