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The association was significant, with higher BMI categories at baseline showing greater decline compared to the lowest BMI category
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
commonly used off-label for weight loss Mounjaro (tirzepatide) approved for Type 2 diabetes
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However, human data confirming this across all dose ranges is limited
Thus, pre-clinical models with single stressor may not represent a reliable platform for bench-to-bedside transition
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