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They exert direct positive impacts on the coronary vascular endothelium, such as oxidative stress reduction and increase in nitric oxide, which at least partially account for their antihypertensive and antiatherosclerotic properties (39)

Some of it gets through

The flip side is that older adults often have the most to gain from retatrutide cardiovascular benefits, particularly blood pressure reduction and weight loss

Higher doses may actually accelerate any desensitization that occurs