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Mol Cell 12:553563
Description Dihexa is a small peptide derived from angiotensin IV, designed to enhance cognitive function and promote synaptogenesis
First, 3-phosphoglycerate is oxidized to 3-phosphohydroxypyruvate with concomitant production of NADH, catalyzed by phosphoglycerate dehydrogenase (PHGDH)
The safety data from animal studies is reassuring
The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001
Claimed outcome Energy changes Evidence level Preclinical or anecdotal What research currently shows NAD+ biology offers a possible mechanism, and informal reports vary
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