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However, the study was cross-sectional, demonstrating association rather than causation
Insulin sensitivity changes: Prolonged high doses may affect insulin signaling
Type 2 diabetes management : FDA-approved doses are calibrated for glycemic control
According to the post-hoc analysis of SURPASS-3 (NCT03882970), 52 weeks of tirzepatide treatment resulted in a 4.4% reduction in MFI in individuals with T2DM [85]
Start with comprehensive baseline measurements before beginning GLP-1 therapy, then follow up after 4-8 weeks to catch early changes
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