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This is most common in people with type 2 diabetes who have been living with chronically elevated glucose levels and suddenly experience rapid correction
Dehydration is another plausible contributor, as gastrointestinal side effects may reduce fluid intake or increase fluid loss
Conclusion Rapid GLP-1 weight loss can affect far more than the number on the scale
While human relevance remains uncertain, patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use either medication
JAMA 302:25652572 Liu Q, Zerbinatti CV, Zhang J, Hoe H-S, Wang B, Cole SL, Herz J, Muglia L, Bu G (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
A dose change under guidance may increase patient comfort and treatment adherence
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