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Another model for Nrf2/Keap-1 activation is the indirect Nrf2 phosphorylation by OS-response kinases such as: PKC (Keum et al., 2003), PI3K (Kang et al., 2002) and PERK (Baird and Dinkova-Kostova, 2011) (Figure 2B)

It is found in high concentrations in tissues such as the heart, skeletal muscles, and brain

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And vitamin C

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some examples are polycystic ovarian syndrome (PCOS) or an underactive thyroid