The basic principle causing the radiation-induced toxicity is the excessive generation of reactive oxygen species (ROS) due to the radiolysis of cellular water, which in turn oxidizes the critical biomolecules such as lipid, protein, and DNA [36,37,38,39]
On average, a therapy session in the United States could cost between $100 and $200 or more
Van asselt DZ, Merkus FW, Russel FG, Hoefnagels WH
doi: 10.1111/mpp.12661 12 DecrosA.MahillonM.GenardM.LienardC.Lima-MendezG.GilmerD.et al
These cellular events might translate into clinical responses like prevention or attenuation of disease states or adverse effects (Figure 1)
[Animal and mechanistic data series from Sikiric's Zagreb group.] Brcic L, Brcic I, Staresinic M, et al