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10.1016/j.cmet.2021.12.005 12 BreretonM

Semaglutide dosing protocol The standard semaglutide titration for weight management follows a well-established 16-20 week escalation schedule: Weeks 1-4: 0.25 mg once weekly Weeks 5-8: 0.50 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance dose) This graduated approach serves two purposes

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Retatrutide will need to demonstrate durability, safety over at least two years, and a tolerable discontinuation rate before it can displace tirzepatide as the top-line agent for most patients